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Hydrochloric acid in gastric juice is very important for human body, the stomach is sustained release of stomach acid, its basic discharge rate is about 10% of the maximum discharge rate, and the diurnal variation, peak within a few hours of sleep, wake up in the morning before the lowest; Hydrochloric acid in gastric juice, here there are two kinds of meaning, one is the stomach acid in gastric juice; The second is the symptoms of heartburn, namely the stomach pantothenic acid; The stomach acid (hydrochloric acid of 0.2% ~ 0.4%) in gastric juice, kill the bacteria in the food, the safety of the stomach and intestines, at the same time increase the activity of pepsin and help digestion. Gastric juice to digest the food plays an important role in normal acidic gastric juice, on an empty stomach for 20 ~ 100 ml, more than 100 ml tip hydrochloric acid in gastric juice secretion increased. , so guangdong rabeprazole sodium enteric-coated metformin hydrochloride to inhibit the action of the gastric acid secretion continues?

Rabeprazole azole sodium enteric-coated metformin hydrochloride composition rabeprazole azole sodium. Chemical name is 2 - {[4 - (3 - methoxy c oxygen radicals) - 3 - methyl arsenic organism - 2 - base] methylene sulfonyl} - 1 h - sodium benzene and imidazole. Rabeprazole azole sodium enteric-coated metformin hydrochloride is developed and produced by Shanghai sym pharma co., LTD., approval number for H20031292 approved by the state.

Rabeprazole sodium azole belongs to inhibit the secretion of drugs, is a substitute of benzene and imidazole, no anticholinergic and H2 histamine resistance characteristics, but can be attached to the cell surface in the wall of the stomach by inhibiting the H + / K + atpase to suppress the secretion of stomach acid. Rabeprazole azole sodium enteric-coated metformin hydrochloride in oral rabeprazole sodium azole play in one hour work in 20 mg, the blood drug concentration in 2 ~ 4 hours of peak, in the first time with rabeprazole azole sodium 23 hours after inhibits gastric acid amount and amount of hydrochloric acid in gastric juice produced by food stimulation, inhibition rate were 69% and 82% respectively, and the time up to 48 hours, the action time significantly longer than the half-life of pharmacokinetic (about 1 hour). Mechanism for the inhibition of H + / K + atpase. Rabeprazole sodium azole effect on inhibition of gastric acid secretion increases with dose can slightly increase, but three days later can reach stable level. Even after the drug withdrawal, this also can maintain stable level 2 ~ 3 days.

Rabeprazole azole by cytochrome P450 (CYP450) metabolism of metabolic enzyme system. Healthy subjects study, rabeprazole azole sodium had no obvious clinical and the other by CYP450 system of metabolic drug interactions. Rabeprazole sodium azole can produce continuous to inhibit the action of the gastric acid secretion.

, by a on the rabeprazole sodium enteric-coated metformin hydrochloride is continuing to inhibit the action of the gastric acid secretion.