麻豆AV出品在线观看_偷偷鲁视频成人免费视频_乱子伦在线观看中文字幕_人碰人摸人爱免费视频在线观看

Search for the keyword:
   
Guangdong pharmacology and toxicology and pharmacokinetic of gamla SiQiong hydrochloride
source:Vitalpharms Company Ltd.    Release date:2017-12-6 10:15:37

Guangdong pharmacology and toxicology and pharmacokinetic of gamla SiQiong hydrochloride

Pharmacology and toxicology 】 【

Pharmacological effects

Guangdong gamla SiQiong hydrochloride is a highly selective 5 - HT3 receptor antagonist, central chemoreception through antagonism area and peripheral vagus nerve endings in the 5 - HT3 receptors, inhibit the occurrence of nausea and vomiting. Guangdong hydrochloride gamla SiQiong high selectivity, without extrapyramidal reactions, such as excessive sedation effects.

Toxicology research

: the acute toxicity of mice and rats a single intravenous hydrochloric acid in guangdong granite SiQiong median lethal dose (LD50) of 17 ~ 25 mg/kg respectively and 14 ~ 16 mg/kg. Subacute and chronic toxicity tests: rats continuous intravenous hydrochloric acid in guangdong granite SiQiong 28 or 13 weeks maximum tolerated dose of 3.0 mg/kg, 0.5 mg/kg; Dog continuous intravenous hydrochloric acid in guangdong granite SiQiong 28 or 13 weeks maximum tolerated dose of 0.3 mg/kg, 0.5 mg/kg, dog intravenous hydrochloric acid in guangdong granite SiQiong 3 mg/kg of mild liver function damage, but found no histological changes.

Reproductive toxicity: rats and rabbits were intravenous hydrochloric acid in guangdong granite SiQiong 9 mg/kg/day 3 mg/kg/day, has not been found that the influence on pregnancy. Guangdong hydrochloride gamla SiQiong no mutagenic effect to mammalian cells.

Carcinogenic test: rats and mice 50 mg/kg/day, 59 weeks, rising incidence of hepatocellular carcinoma and hepatic adenoma.

【 pharmacokinetic 】

Guangdong gamla SiQiong hydrochloride oral absorption quickly and completely, absolute bioavailability of about 90%. Widely distributed, the distribution volume of 174 ~ 258 L, 154 ~ 231 in cancer patients L (by 70 kg the scales), plasma protein conjugation rate is about 65%. Healthy volunteers plasma elimination half-life of 3 ~ 6 hours, the elimination of cancer patients significantly prolong half-life of 9.8 ~ 9.8 hours. Healthy volunteers hydrochloride oral guangdong gamla SiQiong, about 11% of the dose in 48 hours in the form of prototype drug excretion from urine, and the rest of the parts in the form of metabolite excretion in urine and fecal excretion rate of 48% and 38%, respectively. Guangdong gamla SiQiong hydrochloride by liver microsomal metabolism of P - 450-3 a mediated, and the major metabolic pathways for N - demethylation aromatic epoxidation and then combine the product.

Looked at the above introduction, believe everybody already knows guangdong gamla SiQiong hydrochloride of pharmacology and toxicology and pharmacokinetic, if necessary, consult the hydrochloric acid gamla SiQiong supplier specialized in personnel, must be able to solve your problem. Hope these information can help to you.

 


Keywords: guangdong gamla SiQiong hydrochloric acid, hydrochloric acid gamla SiQiong suppliers

Previous:Taking hydrochloric acid granite SiQiong matters needing attention/
Next:Introduction of omeprazole micro pill

About Us
Company Profile
Culture
Qualification
Staff style
Organization
News
Company News
Industry news
Media coverage
Products
Agent Products
Intermediates
Associated with the review and intermediates
Animal health related products
Merchants joined
Industry Standard
Quality certification
Contact Us
Vitalpharms Company Ltd.
Add.: 2/F, 3# Buliding, 169 Shihua Rd. West, Zhuhai, Guangdong, China.
Tel: +86-756-3326819/ 3221531
Fax: +86-756-3326816
E-MAIL: sales@www.palmbeachunited.com
Copyright©Vitalpharms Company Ltd.  Internet Drug Information Service Qualification Certificate: (Guangdong)- Non-operational -2023-0028   粵ICP備10097759號